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Based on preclinical and limited clinical studies, berberine's primary metabolic effects appear to occur through activation of AMP-activated protein kinase (AMPK), an enzyme that serves as a cellular energy sensor

Cell 75:5972 Woods KA, Camacho-Hbner C, Savage MO, Clark AJ (1996) Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene

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